Editors: Misa Nakamura, Kennichi Kakudo

Molecular Mechanism and Morphology in Cancer

eBook: US $59 Special Offer (PDF + Printed Copy): US $136
Printed Copy: US $107
Library License: US $236
ISBN: 978-1-60805-387-2 (Print)
ISBN: 978-1-60805-073-4 (Online)
Year of Publication: 2009
DOI: 10.2174/97816080507341100101

Introduction

The WHO report estimates that 12 million people will be diagnosed with some form of cancer this year. In addition, the report predicts that more than 7 million people will die early from the disease. Together, the number of cancer cases and deaths from cancer are expected to increase by one percent each year. Cancer research has seen remarkable advancements, including the multi-step carcinogenesis theory and the identification of a cancer stem cell. These advancements are being applied to clinical therapies targeting the oncogene. In addition, the function of the gene product is becoming clear through analysis of the intracellular signaling of the oncogene. As a result, it has become clear that the morphologies of the cancers depend on the kind of the abnormal gene. Of course, these differences would influence patient’s life and death and is summarized by specialists in this area. This theme includes the full range of human diseases regarding medical genetics, biochemistry, microbiology, immunology, anatomy, pathology, structural biology, molecular cell biology, neuroscience and developmental biology. The eBook contains articles written by specialists in this area. It should prove to be of great use to clinicians and scientists in all medical fields.

Preface

- Pp. i-iii (1)
Misa Nakamura
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Foreword

- Pp. ii
Liang Shan
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Contributors

- Pp. iii-iv (2)
Misa Nakamura and Kennichi Kakudo
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Gastrointestinal Stromal Tumors: Mutations of Receptor Tyrosine Kinases and Morphology

- Pp. 1-11 (11)
Seiichi Hirota and Koji Isozaki

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Pathology and Molecular Biology of Renal Neoplasms: Recent Advances and Impacts on Pathological Classification

- Pp. 12-41 (30)
Yoji Nagashima, Naohito Kobayashi, Eriko Kagawa, Ichiro Aoki, Yoshiaki Inayama and Masahiro Yao

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Chemotherapy in Malignant Gliomas

- Pp. 42-56 (15)
Mitsutoshi Nakamura, Keiji Shimada, Hiroyuki Nakase and Noboru Konishi

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The Role of Bcl-2 in Breast Cancer

- Pp. 57-80 (24)
Xiaoyan Li and Qifeng Yang

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ETS Gene Fusions in Prostate Cancer

- Pp. 81-101 (21)
Bo Han

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New Types of Cell Death: Morphological and Molecular Characteristics

- Pp. 102-119 (18)
Takashi Ozaki, Ichiro Mori, Katsuyoshi Tabuse, Takaomi Suzuma, Takeo Sakurai, Misa Nakamura, Emiko Taniguchi and Kennichi Kakudo

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Thyroid Cancer: Gene Mutation and Morphology of Follicular Cell Carcinomas

- Pp. 120-137 (18)
Misa Nakamura, Yaqiong Li, Zhiyan Liu and Kennichi Kakudo

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Index

- Pp. 138-144 (7)
Misa Nakamura and Kennichi Kakudo
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