Multidisciplinary research involving crystallography, kinetic studies, molecular docking, genetics and other techniques in biochemistry has yielded a wealth of knowledge about the reaction mechanisms in cellular processes. This knowledge has allowed researchers to understand, in a better way, the normal functioning of the cell process, which is used as a reference point for learning about and preventing or correcting pathologies that cause diseases.

'Enzymes Involved in Glycolysis, Fatty Acid and Amino Acid Biosynthesis: Active Site Mechanism and Inhibition' is a thorough compendium about reaction mechanisms occurring between the major enzymes related to the biosynthetic pathways of 3 important types of biological compounds - 6-carbon carbohydrates, fatty acids and amino acids - and their substrates, cofactors and residues. Readers will gain an understanding of the interaction between substrates or ligands with specific amino acid residues in biosynthetic enzymes. This understanding builds a foundation for learning about the biochemistry of different inhibitors used in the treatment of several diseases such as cancer, infectious diseases, and metabolic syndrome alterations such as diabetes and obesity.

Enzymes covered in the book include aldolases, isomerases, kinases, mutases, synthases, dehydrogenases, reductases, transferases, hydrolases, lyases among others, all of which are wide spread in biochemical transformations.

This reference, with its insights on common biochemical enzymes serves as a handy guide for students, researchers and professionals involved academia or industry related to pharmaceutical development, healthcare, food chemistry and other disciplines.

About the Editor:

Marco Brito-Arias carried out his bachelor studies at the National Polytechnic Institute of Mexico, obtaining the degree as a pharmaceutical industrial chemist, followed by masters in science courses of bioorganic chemistry. After a short period working in a pharmaceutical company, he decided to continue his PhD studies at the University of Gent Belgium, from 1988 to 1993, on the synthesis of hypermodified nucleotides, and substrates for enzymatic detection in the group of Marc Van Montagu, obtaining the title with Magna cum Laude distinction. The results of this research were published in The Plant Cell, 1993, 5, 1761 (Cover page) and Plant Cell Reports, 2000, 19, 966. After finishing his PhD studies, he joined the chemistry institute at the National University of Mexico, for conducting research on heterocyclic chemistry in 1993 till 1995 and after that period, he got a position as professor of chemistry at the Biotechnology Unit of the National Polytechnic Institute where he is currently teaching subjects, namely, bioorganic chemistry, drug design and heterocyclic chemistry. In 2002, he spent a year as a postdoc at the University of California Berkeley researching the first synthesis of glycoresin, tricolorin F at the laboratory of Professor Clayton Heathcock. The result of this research was published in the Journal of Organic Chemistry, 2004, 69, 4567 (Cover page).

Keywords:

Enzymes, food chemistry, biochemical transformations, biosynthetic enzymes, biological compounds, amino acid

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