Halogenated pyridines can be used as interesting starting materials in a wide range of organic synthesis methods. Substituted pyridine compounds are used generally as starting materials in the nucleophilic substitution reactions and have unique scaffolds for the construction of other heterocyclic and macrocyclic compounds. They also have important medicinal properties. Due to synthetic difficulties in the synthesis of the highly substituted pyridine derivatives from pyridine itself, perhalopyridines have a special importance in this regard.
Perhalopyridines: Synthesis and Synthetic Utility covers the synthetic reactions and applications of perhalopyridines. An introductory chapter introduces the reader to the physical and chemical properties of halopyridines, followed by 3 chapters which focus on pentafluoropyridine, pentachloropyridine and pentabromopyridine, respectively. The focused chapters provide information about synthetic methods and relevant nucleophilic reactions for each of the listed perhalopyridines and their derivatives.
About the Editors:
Dr. Reza Ranjbar-Karimi is a Professor of organic chemistry at the Vali-e-Asr University of Rafsanjan (IRAN). After studying chemistry in the faculty of chemistry at Isfahan University, he obtained his PhD in 2006 with Professor Majid Mirmohammad-Sadeghi and Professor Hossein Loghmani-Khuzani. After a research course stay with Professor Graham Sandford at Durham University (UK), he started his independent research obtaining a permanent position first as assistant professor and associated professor (2010) and obtaining full professorship in 2015. His main interests of research concern the synthesis of halogenated heterocyclic compounds via perhalogenated pyridines.
Dr. Alireza Poorfreidoni obtained his PhD in 2015 with Professor Reza Ranjbar-Karimi at the Vali-e-Asr University of Rafsanjan (IRAN). His main interests of research concern the synthesis of polynitrogen heterocyclic compounds and halogenated heterocyclic compounds.
Keywords: Halogenated pyridines, perhalopyridines, pentafluoropyridine, pentachloropyridine, pentabromopyridine, macrocyclic compounds, heterocyclic compounds, organic synthesis methods, nucleophilic reactions
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