Chapter 12

Pseudovirus Neutralization Assay for SARS-CoV-2

Ankush Sharma, Sneha Joshi, Pooja Patni, Navneet Khurana and Devesh Tewari*

Abstract

The World Health Organization (WHO) has indicated coronavirus disease- 19 (COVID-19) as a global pandemic. A virus that is formed by the recombination process and whose genetic material as well as protein-rich envelope are resulting out of various viruses is known as pseudovirus. There are certain advantages of using pseudovirus over native viruses. Due to several novel viruses e.g., Marburg virus, Ebola virus, Lassa fever virus, immunodeficiency virus, and coronavirus, there is a development of numerous packing arrangements to produce pseudotype virus having envelope in their structure. This chapter deals with various virus packaging systems with a focus on production and neutralization assay of pseudovirus.

Total Pages: 315-336 (22)

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