Chapter 5

Mutation of SARS-CoV-2

Umair Younas* and Kashif Prince

Abstract

Coronavirus undergoes more frequent mutations over time. It is well understood with previous outbreaks of the diseases, like the severe acute respiratory syndrome (SARS) and the Middle East respiratory syndrome-coronavirus (MERSCoV). The behavior and pattern of diseases change with the mutation, and the virus becomes a new virus of its out kind regarding morbidity and mortality. Virus from different origins has been observed to have mutations at various places of their genome resulting in changed disease pattern resulting in the worldwide outbreak of the coronavirus disease-19 (COVID-19). Mutation in coronavirus is a slow and emerging process that may be responsible for the modulation of viral transmission, virulence, and replication efficiency in different regions of the globe. SARS-CoV-2 is going to spread around the world, and novel mutation hotspots are emerging in the genome. There has been increasing in the genetic diversity of coronavirus in human hosts. Random mutations cause the diversification of the virus leading to drug resistance, the changed pathogenicity and infectivity. This variation could remain in the virus, but it could be transferred to the next generation. The study was conducted to focus on viral evolution through mutation in various geographic regions of the world.

Total Pages: 133-161 (29)

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