Chapter 3

Basic and Advanced Electrochemical Technology for Biosensing Applications

Tien-Chun Tsai, Neil Adrian P. Ondevilla and Hsien-Chang Chang


Electrochemical biosensors combine a molecular recognition concept involving the use of biosensors to sensitively detect target analytes with an attractive electrochemistry technique to analyze a biological sample due to the direct conversion of a biological event to an electronic signal. The strength of electrochemical biosensors allows sensitive, label-free biosensing with highly temporal resolution using a miniature instrument. This chapter commences with a fundamental introduction of the electrochemical principles, as well as providing a technological comparison between general voltammetric measurements, including cyclic voltammetry (CV), differential pulse voltammetry (DPV), and square wave voltammetry (SWV). It continues with a broad, detailed description of various electrochemical applications ranging over ionselective electrodes, an enzyme-catalyzed / non-enzymatic glucose sensor, an aptamerbased biosensor (aptasensor), and a genosensor for nucleic acids. This chapter provides readers with a good insight into the usefulness, performance, and properties of electrochemical biosensors with many examples.

Total Pages: 64-98 (35)

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