Sex Steroids and Apoptosis In Skeletal Muscle: Molecular Mechanisms


Andrea Vasconsuelo

DOI: 10.2174/97898114123631190101
eISBN: 978-981-14-1236-3, 2019
ISBN: 978-981-14-1235-6

This monograph focuses on the actions exerted by sex hormones, 17β-estradiol and testosterone, in skeletal muscle tissue. An important co...[view complete introduction]
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Estrogens and Androgens Binding Sites in Mitochondria

- Pp. 73-79 (7)

Lorena M. Milanesi


Mitochondrial localization of estrogen and androgen receptors and hormone-responsive elements (EREs) was reported in different cell lines and indicated that these steroid hormones have specific actions on the mitochondrial gene expression and functions. Both steroids act through a complex molecular mechanism that involves crosstalk between plasma membrane, mitochondria and nucleus. One of the results of these interactions is mitochondrial protection. Here, we discuss studies that describe the estrogen- and testosterone-dependent actions on the mitochondrial and their implications.

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