Chapter 4

The Development and Clinical Progress on Chemokine Receptor-Based HIV Entry Inhibitors

Yi-Qun Kuang

Abstract

Entry of HIV-1 into targeted host cells is a highly ordered multistage process involving first-receptor attachment, co-receptor binding, and membrane fusion. In this chapter, I will present an overview of progress on HIV-1 entry inhibitors with a focus on chemokine receptor-based antagonists. This chapter, at first, will describe the working mechanisms of chemokine receptors, HIV-1 co-receptors CCR5 and CXCR4, during the replication procedure. Then, the antagonists-based on different mechanisms will be presented in detail. At last, it will summarize and explain the distinct promising entry inhibitors based on co-receptors-interacting proteins, which is inspired by our current work.

Total Pages: 105-137 (33)

Purchase Chapter  Book Details

RELATED BOOKS

.Biologically Active Natural Products from Asia and Africa: A Selection of Topics.
.Endocannabinoids: Molecular, Pharmacological, Behavioral and Clinical Features.
.Frontiers in Clinical Drug Research-Anti-Infectives.
.COVID-19: Epidemiology, Biochemistry, and Diagnostics.
.Frontiers in Anti-infective Agents.
.Coronaviruses.
.Influenza: A Century of Research.