Chapter 1

Adverse Drug Reactions

Ioan Jung and Simona Gurzu


This chapter includes general aspects regarding the definitions and mechanisms of occurrences of adverse drug reactions (ADRs). They can be realized through non-immunological (type A reaction) or immunological (type B reaction) pathways and can be dose-dependent or independent. A new type of ADR is encountered in oncology departments in patients taking monoclonal antibodies. It is known as drug-induced apoptosis and is presented in this chapter. The mechanisms and classification of the severity of these reactions, as well as the particularities of acute, chronic and chronic-delayed ADRs, are also explored. The severity can be patient- or drug-related. In the chapters that follow, specific system- and organ-related ADRs are presented.

Total Pages: 1-6 (6)

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