Nanomedicine and Neurosciences: Advantages, Limitations and Safety Aspects

Book Series: Frontiers in Nanomedicine

Volume 2


Giovanni Tosi

DOI: 10.2174/97816810851281170101
eISBN: 978-1-68108-493-0, 2017
ISBN: 978-1-68108-494-7
ISSN: 2405-9129 (Print)
ISSN: 2405-9137 (Online)

Frontiers in Nanomedicine offers an up-to-date understanding of nanomaterials to readers having clinical or biomolecu...[view complete introduction]
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Neuronal Mechanisms for Nanotopography Sensing

- Pp. 101-114 (14)

Ilaria Tonazzini and Marco Cecchini


Cell contact interaction with extracellular environment cooperates in coordinating several physio-pathological processes in vivo, and can be exploited to manipulate cell responses in vitro. Thanks to recent developments in micro/nanoengineering techniques, nano/micro-structured surfaces have been introduced capable of controlling neuronal cell adhesion, differentiation, migration, and neurite orientation by interfering with the cell adhesion machinery. In particular, this process is mediated by focal adhesion (FA) establishment and maturation. FAs cross-talk with the actin fibers and act as topographical sensors, by integrating signals from the extracellular environment. Here, we describe the mechanisms of nanotopography sensing in neuronal cells. In particular, experiments addressing the role of FAs, myosinIIdependent cell contractility, and actin dynamics in neuronal contact guidance along directional nanostructured surfaces are reviewed and discussed.

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