Chapter 5

Monoamine Oxidase-A: A Valid Target for the Management of Depression

Bijo Mathew and Jerad Suresh

Abstract

Monoamine oxidase enzyme has been developed as a valid target for the treatment of depression. The development of selective and reversible type of monoamine oxidase-A inhibitors still remains a challenge to medicinal chemists pursuing the research towards the search of innovative chemotypes for the management of depressive states. The present chapter focuses on the history of MAO-A inhibitors, structure and biochemistry of MAO-A. It also covers challenges involved in the drug development of MAO-A inhibitors.

Total Pages: 126-134 (9)

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