Chapter 15

Intrahepatic Cholangiocarcinoma

David Fuks and Olivier Farges

Abstract

• Clinical presentation and management of intrahepatic cholangiocarcinoma (IHCC),the second most frequent primary liver tumor (after hepatocellular carcinoma), depend on the location of origin (juxtahilar to end-order biliary branches).</p><p> • In addition to classical risk factors for IHCC (such as parasitic infections, bile ductectasia, and primary sclerosing cholangitis), hepatitis B and C virus infection,cirrhosis, obesity, diabetes, and genetic polymorphisms seem to play a role in IHC Corigin. </p><p> • The three pathological subtypes – mass-forming, periductal-infiltrating, and intraductal-growth tumors – present different biological behavior and imaging characteristics. </p><p> • Surgical resection of IHCCs carries high morbidity and mortality rates, but it is currently the only curative treatment for IHCC, with a 5-year overall survival rate of 27%. Recurrence is frequent, rarely amenable for repeat surgery, and usually associated with death. The role of liver transplantation is controversial.

Total Pages: 237-252 (16)

Purchase Chapter  Book Details

RELATED BOOKS

.Abdominal Pain: Essential Diagnosis and Management in Acute Medicine.
.Clinical Mechanics in the Gut: An Introduction.
.Comprehensive Practical Hepatology.
.Oesophago-gastric Surgery.