In this chapter, we briefly discuss the role of ion channels, specifically calciumdependent K<sup>+</sup> channels (BKCa) and ATP-sensitive K<sup>+</sup> channels (KATP) channels in glioma biology and BTB permeability regulation. We have discussed our work on brain tumors, which are associated with over-expression of BKCa and KATP channels. Finally, we discuss how we targeted BKCa and KATP channels in the BTB to deliver anti-cancer drugs and imaging agents to brain tumors by breaching the BTB. We conclude that antineoplastic drug and imaging agents’ delivery can be enhanced selectively to brain tumors by targeting ion channels on BTB. This strategy has no side effects but may help in tumor regression.
Total Pages: 231-246 (16)
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