Chapter 3

Alternative Biomaterial Substrates for Human Embryonic Stem Cell Culture

Deepak Kumar, Ying Yang and Nicholas R. Forsyth


The additive effect of stem cell therapy and biomaterial substrates provides exciting opportunities for tissue engineering and regenerative medicine applications. Nanofibrous substrates can be fabricated to mimic the nano-architectural structure of specific, native tissue extracellular matrix. This provides topographical structure and contact guidance, which can impact stem cell biology as well as direct their differentiation towards specific lineages. This chapter highlights nanofibrous substrates as an alternative tool for the expansion and differentiation of embryonic stem cells. Future applications of such technology could promote the use of hESC-derived cells for clinical applications.

Total Pages: 65-91 (27)

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.Frontiers in Stem Cell and Regenerative Medicine Research.
.Bone Marrow Aspirate Concentrate and Expanded Stem Cell Applications in Orthopaedics.
.Developmental and Stem Cell Biology in Health and Disease.
.Frontiers in Pluripotent Stem Cells Research and Therapeutic Potentials Bench-to-Bedside.