Chapter 14

Targeting Molecular Mechanisms of Cognitive Dysfunction

Rafael Roesler, Arethuza S. Dornelles and Fernando Benetti


Increasing knowledge of the neurobiological basis of synaptic plasticity and memory has opened new venues for the development of cognitive-enhancing drugs that could be used in the treatment of memory loss associated with neurological and psychiatric disorders. Neuromodulatory systems influencing memory formation include stress hormones as well as a range of neurotransmitter and neuropeptide signaling pathways. Here, we review some of the findings on memory enhancement by drugs acting on neuromodulatory systems and discuss the possible implications for the development of cognitive enhancers.

Total Pages: 327-340 (14)

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.Frontiers in Clinical Drug Research - CNS and Neurological Disorders.
.Frontiers in Clinical Drug Research-Dementia.
.Advances in Alzheimer Research.
.Recent Advances in the Treatment of Neurodegenerative Disorders.
.Advances in Alzheimer Research.
.Cellular and Molecular Biology of Autism Spectrum Disorders.