Chapter 5

Nitric Oxide as an Adjuvant Therapeutic in the Clinical Management of Cancer

Nicole J. Kenote, Tysha N. Medeiros, Dana M. Jarigese, Melissa A. Edwards and Mark A. Brown

Abstract

The ability of tumors to develop resistance to cytotoxic therapies has been a major obstacle in the clinical management of cancer. In addition, dose-limiting toxicity represents yet another impediment in the application of traditional therapeutics. To enhance the sensitivity of tumors to radio-therapeutics, researchers are increasingly turning to nitric oxide for its potential as a powerful adjuvant to existing therapies. Here, we review the aptitude of nitric oxide to serve as a radio-sensitizing, adjuvant therapeutic for the clinical management of cancer.

Total Pages: 191-200 (10)

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