Chapter 3

The Hallmarks of Physiologic Antibody Immunity in Cardiac Diseases and its Impact to Personalized Medicine

Olga M. Moiseeva, D.A. Grigoŕeva and Sergey V. Skurydin

Abstract

Immune system plays a great physiological role in maintaining of heart tissue homeostasis. This concerns numerous proteins, expressed in myocardium in norm (heart proteomics) and, of course, their “fingerprints” in mirror of immunculus (heart immunomics of main immunogenic region B-epitopes). In this chapter we tried to reveal the problem of cardiac specific proteins, their impact in heart physiology and local autoimmunity, the mechanisms of their formation and approaches for highly specific immunotherapy, based on their profiles in dynamics of pharmacological treatment. Here we discuss implications of antibody therapy and antibody elimination, peptide therapy and immunomodulation under guidance of physiological immunity, partially based on recently received data.

Total Pages: 46-71 (26)

Purchase Chapter  Book Details

RELATED BOOKS

.Personalized Immunotherapy for Tumor Diseases and Beyond.
.Frontiers in Clinical Drug Research – Anti Allergy Agents.
.Meta-inflammation and Obesity.
.Antibodies Applications and New Developments.