Chapter 6

Tripentones: A Promising Series of Potent Anti-Cancer Agents

Christophe Rochais, Sylvain Rault and Patrick Dallemagne


The 8H-thieno[2,3-b]pyrrolizinones, some of which exert very potent cytotoxic activity against tumor cell lines in vitro, are a promising novel series of anticancer agents. These compounds belong to the tripentone family and are based on 9Hpyrrolo[ 1,2-a]indol-9-one derivatives and their heterocyclic isosteres. This paper inventories the different synthetic strategies for tripentones and reviews their biological effects and therapeutic potential.

Total Pages: 313-343 (31)

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