Chapter 8

Advances in the Synthesis of Organometallic Amino Acids and Analogues

Poulami Jana, Sibaprasad Maity and Debasish Haldar

Abstract

Incorporation of metal chelating amino acids in protein or peptide sequences helps protein purification due to the metal ion affinity of the protein or peptide. Structure and function of synthetic amino acids with side chain metal complexes have particular importance for extending our understanding of organometallic compounds under physiological conditions and mimic protein folding and stabilization. Chemists are now designing biomimetic organo-metallic amino acids that can form both secondary and tertiary structures through various noncovalent interactions. An overview of the design and synthesis of non-proteinogenic amino acids containing metal ions in the side chain is discussed.

Total Pages: 355-378 (24)

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