Chapter 6

An Update on Trifluoromethylation of Carbonyl Compounds

Nubia Boechat and Monica Macedo Bastos


This chapter reviews the recent findings on the synthetic methods developed for the direct introduction of a trifluoromethyl group in carbonyl compounds. It was organized by type of reagent highly considering the description of the trifluoromethylating agents, their activation mode, their asymmetric approaches, as well as applications in organic synthesis.

Total Pages: 279-308 (30)

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.Advances in Organic Synthesis.
.Modern Organofluorine Chemistry-Synthetic Aspects.