Chapter 6

Biocatalysis in the Preparation of the Statin Side Chain

Arto Liljeblad, Annukka Kallinen and Liisa T. Kanerva


Statins used in the treatment of dyslipidemias are top-selling drugs in the world. Economical production of statins in industrial scale is challenging, because the side chain of statins is a 3,5-dihydroxyacid derivative consisting of two asymmetric centers. The most prominent methods for the preparation of the side chain are based on biocatalysis and surveyed in this review.

Total Pages: 195-236 (42)

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.Advances in Organic Synthesis.
.Modern Organofluorine Chemistry-Synthetic Aspects.
.Advances in Organic Synthesis.