Chapter 7

Gel-Forming Mucin MUC6

Joseph Z. Zaretsky and Daniel H. Wreschner

Abstract

The MUC6 mucin plays an essential role mainly in homeostasis of the gastrointestinal tract, and in pathogenesis of many diseases associated with the gastrointestinal, respiratory, and male and female urogenital systems. The structure of the MUC6 gene and the mechanisms that regulate its activity are analyzed in this chapter. The biochemical and biophysical properties of the MUC6 glycoprotein, its biosynthesis, posttranslational modifications, and expression in various cells and tissues are discussed.

Total Pages: 316-386 (71)

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