Recent Advances in Insects and Other Arthropods

Book Series: Hemolymph Proteins and Functional Peptides

Volume 1


Muhammad Tufail, Makio Takeda

DOI: 10.2174/97816080540151120101
eISBN: 978-1-60805-401-5, 2012
ISBN: 978-1-60805-402-2
ISSN: 2589-3084 (Print)
ISSN: 2213-2694 (Online)

Indexed in: Book Citation Index, Science Edition, BIOSIS Previews, Zoological Record, EBSCO, Ulrich's Periodicals Directory.

Recent molecular studies have revealed an overwhelming role of hemolymph proteins and functional peptides in invertebrate physiology. ...[view complete introduction]
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Insulin-Related Peptides in Insects and Other Arthropods

- Pp. 161-171 (11)

Takumi Suzuki and Masafumi Iwami


Insulin was discovered as a key regulator of blood sugar level in 1922. In invertebrates, an insulin-like peptide, now named as bombyxin, was first isolated from the silkworm, Bombyx mori, with its prothoracicotropic activity to the saturniid moth, Samia cynthia ricini, in 1984. After the isolation of the peptide, homologous peptides were found in multiple insect and crustacean species. The insulin signaling pathway has also been recognized as a widely conserved pathway among animals. The conservations of molecular structure and signal pathway indicate that insulin has been one of the most important hormones discovered thus far. In this review, we summarize the molecular aspects of insulin and insulin-like (-related) peptides and then focus on their physiological functions in respect of sugar and lipid metabolisms, hormone biosynthesis, and developmental control such as body size and lifespan. We will make it clear that insulin and insulin-like peptide of arthropods are not just the hormones that regulate blood sugar levels but the strategic key hormones of growth and development. The functions of insulin and insulin-like peptide have been evaluated for hypotrehalosemic and hypoglycemic activities, ecdysteroidogenesis, juvenile hormone synthesis and secretion, lipid metabolism. In addition, they have been now recognized as main regulators of growth, lifespan, and reproduction.

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