Sialobiology: Structure, Biosynthesis and Function Sialic Acid Glycoconjugates in Health and Disease


Joe Tiralongo, Ivan Martinez-Duncker

DOI: 10.2174/97816080538651130101
eISBN: 978-1-60805-386-5, 2013
ISBN: 978-1-60805-067-3

Indexed in: Book Citation Index, Science Edition, BIOSIS Previews, Scopus, EBSCO.

This eBook presents a summary of central aspects of sialobiology (i.e., the study of sialic acid and its relevance to biology). The im...[view complete introduction]
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Vertebrate Sialyltransferases

- Pp. 139-187 (49)

Anne Harduin-Lepers


Sialyltransferases are a subset of glycosyltransferases catalyzing the transfer of sialic acid (Sia) residues from an activated sugar donor onto glycoconjugates. The aim of this chapter is to summarize in a comprehensive review what is known about vertebrate sialyltransferases structural features, the lessons drawn from molecular biology and the production of recombinant proteins and to explore the relationships between their primary structure and function. Insights into vertebrate sialyltransferases origin and evolution using bioinformatic approaches, screening of nucleotide databases of various animal organisms (vertebrates and invertebrates), molecular phylogeny and phylogenomic will be discussed.

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