Sialobiology: Structure, Biosynthesis and Function Sialic Acid Glycoconjugates in Health and Disease

by

Joe Tiralongo, Ivan Martinez-Duncker

DOI: 10.2174/97816080538651130101
eISBN: 978-1-60805-386-5, 2013
ISBN: 978-1-60805-067-3



Indexed in: Book Citation Index, Science Edition, BIOSIS Previews, Scopus, EBSCO.

This eBook presents a summary of central aspects of sialobiology (i.e., the study of sialic acid and its relevance to biology). The im...[view complete introduction]
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Sialic Acid Biosynthesis in Vertebrates

- Pp. 76-114 (39)

Anja K. Münster-Kühnel and Stephan Hinderlich

Abstract

Sialic acids (Sia) represent a family of nine-carbon keto-sugars with an unusual high structural diversity. However, all members are biosynthetic derivatives of either N-acetylneuraminic acid or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid. In this chapter, we describe the biosynthesis of these two Sia precursors in vertebrates with a focus on the characteristiscs of the involved enzymes. In addition, the activation of the sugars as well as the degradation is included. Furthermore, dieseases and mouse models associated to the Sia biosynthesis pathway as well as biomedical implications are addressed.

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