Sialobiology: Structure, Biosynthesis and Function Sialic Acid Glycoconjugates in Health and Disease

by

Joe Tiralongo, Ivan Martinez-Duncker

DOI: 10.2174/97816080538651130101
eISBN: 978-1-60805-386-5, 2013
ISBN: 978-1-60805-067-3



Indexed in: Book Citation Index, Science Edition, BIOSIS Previews, Scopus, EBSCO.

This eBook presents a summary of central aspects of sialobiology (i.e., the study of sialic acid and its relevance to biology). The im...[view complete introduction]
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Introduction to Sialic Acid Structure, Occurrence, Biosynthesis and Function

- Pp. 3-32 (30)

Joe Tiralongo

Abstract

Sialic acids (Sia) are a family of 9-carbon α-keto acid aminosugars found predominantly at the non-reducing end of oligosaccharide chains on glycoproteins and glycolipids. Since their discovery in the late 1930s, and subsequent naming by Blix, Gottschalk and Klenk (Nature. 1957; 179: 1088), Sia are now recognized as occurring ubiquitously in nature (except plants), and being involved in numerous biologically important processes. In particular, the growing awareness of the significance of Sia in human health and disease has led to an increase in research into Sia chemistry, biochemistry and cell biology. In this chapter, the structure and occurrence of Sia will be summarized, as well as aspects of Sia chemistry, biochemistry and cell biology not covered in subsequent chapters of this eBook are also presented. Throughout this, and subsequent chapters of this eBook the abbreviations and nomenclature summarised in Schauer and Varki, (In Essentials of Glycobiology 2<sup>nd</sup> Ed, Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009) will be used. Importantly, wherever appropriate the reader will be directed to the relevant chapters of this eBook, or extensive reviews for further detail.

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