Chapter 6

Effect of Genetic Background on Ionotropic Glutamate Receptor and Neurotrophin Biology: Synaptic Connectivity and Function in Neurological Disease

Gregory N. Barnes and John T. Slevin

Abstract

<p>Glutamate receptor signaling is essential to normal synaptic function in the central nervous system. The major ionotropic glutamate receptors (AMPA, Kainic, and NMDA) have different synaptic functions depending upon cellular and subcellular localization, subunit composition, and second messenger systems linked to the receptors. In this review, we examine major advances in glutamate receptor biology whose physiology plays a central role in neurologic disease such as epilepsy and stroke. A key feature of glutamate receptor activation in neurologic disease is the downstream effects on cell survival, genetic expression of axon guidance cues, synaptic connectivity/formation of networks, and neuronal excitability. Identification of therapeutic pharmacologic targets and development of antagonists specific to the disease process remain central themes in epilepsy and stroke research.</p>

Total Pages: 111-132 (22)

Purchase Chapter  Book Details

RELATED BOOKS

.Science of Spices and Culinary Herbs - Latest Laboratory, Pre-clinical, and Clinical Studies.
.Science of Spices and Culinary Herbs - Latest Laboratory, Pre-clinical, and Clinical Studies.
.Medicinal Chemistry of Drugs Affecting the Nervous System.
.Advances in Anticancer Agents in Medicinal Chemistry.