Current Trends of the Supercritical Fluid Technology in the Pharmaceutical, Nutraceutical and Food Processing Industries


Ana Rita C. Duarte

DOI: 10.2174/97816080504681100101
eISBN: 978-1-60805-046-8, 2010
ISBN: 978-1-60805-661-3

Indexed in: Book Citation Index, Science Edition, Scopus, EBSCO.

Supercritical fluid technology can be seen as a green and environmentally friendly alternative to conventional. Current information on...[view complete introduction]
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Supercritical Fluid Impregnation for the Preparation of Controlled Delivery Systems

- Pp. 52-60 (9)

Ana Rita C. Duarte and Catarina M. M. Duarte


Controlled drug delivery products, using biocompatible or biodegradable polymers, have received considerable attention in the last years. These substances provide in general a more controlled release rate of assumption of the drug by the body improving its therapeutic action. In fact, there is a growing interest of the pharmaceutical industry in the development of these systems. Impregnation using supercritical fluid technology has already proven its feasibility, in the preparation of controlled release systems. In this technique the drug component is dissolved in a compressed gas (carbon dioxide) that is used as a mobile phase and that, also, swells and stretches the polymer matrix, facilitating the diffusion of the drug, and increasing the rate of impregnation. A high purity product, free of residual solvents is obtained, since no organic solvents are involved in the impregnation process. In this chapter, the development of different successful controlled release systems is presented.

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