Chapter 5

DIMENSIONS OF GLOBAL BRAIN INVOLVEMENT

Lawrence M. Agius

Abstract

Relative attempts at modulation and manipulative processing of neurotransmitter release and receptivity at the post-synaptic membrane appear central to the consequences of synaptic loss in Alzheimer’s disease. In view of the ongoing dynamics of further injury to neurons in this disorder, it would perhaps prove important to recognize consequences of disease as themselves pathogenic targets in the evolutionary definition of further injury as progression, particularly in terms of both neuronal cell and synapse loss.

Total Pages: 47-56 (10)

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